FCGRT

Fc fragment of IgG receptor and transporter
معرفات
أسماء بديلة	transmembrane alpha chain of the neonatal receptor, Fc fragment of IgG, receptor, transporter, alpha, Neonatal Fc receptor, IgG receptor FcRn large subunit p51, neonatal Fc-receptor for Ig, heavy chain of the major histocompatibility complex class I-like Fc receptor, major histocompatibility complex class I-like Fc receptor, FCGRT, FcRn alpha chain, IgG Fc fragment receptor transporter alpha chain, immunoglobulin receptor, intestinal, heavy chain
معرفات خارجية
تماثلات متسلسلة
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

FCGRT‏ (Fc fragment of IgG receptor and transporter) هوَ بروتين يُشَفر بواسطة جين FCGRT في الإنسان.^[1]^[2]^[3]

الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]

^ "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha". مؤرشف من الأصل في 2010-12-05.
^ Story CM، Mikulska JE، Simister NE (ديسمبر 1994). "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus". J. Exp. Med. ج. 180 ع. 6: 2377–81. DOI:10.1084/jem.180.6.2377. PMC:2191771. PMID:7964511.
^ Kandil E، Egashira M، Miyoshi O، Niikawa N، Ishibashi T، Kasahara M، Miyosi O (يوليو 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet. Cell Genet. ج. 73 ع. 1–2: 97–8. DOI:10.1159/000134316. PMID:8646894.

قراءة متعمقة[عدل]

Dürrbaum-Landmann I، Kaltenhäuser E، Flad HD، Ernst M (1994). "HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro". J. Leukoc. Biol. ج. 55 ع. 4: 545–51. PMID:8145026.
Leach JL، Sedmak DD، Osborne JM، Rahill B، Lairmore MD، Anderson CL (1996). "Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport". J. Immunol. ج. 157 ع. 8: 3317–22. PMID:8871627.
Kivelä J، Parkkila S، Waheed A، Parkkila AK، Sly WS، Rajaniemi H (1997). "Secretory carbonic anhydrase isoenzyme (CA VI) in human serum". Clin. Chem. ج. 43 ع. 12: 2318–22. PMID:9439449.
Vaughn DE، Bjorkman PJ (1998). "Structural basis of pH-dependent antibody binding by the neonatal Fc receptor". Structure. ج. 6 ع. 1: 63–73. DOI:10.1016/S0969-2126(98)00008-2. PMID:9493268.
West AP، Bjorkman PJ (2000). "Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)". Biochemistry. ج. 39 ع. 32: 9698–708. DOI:10.1021/bi000749m. PMID:10933786.
Mikulska JE، Pablo L، Canel J، Simister NE (2000). "Cloning and analysis of the gene encoding the human neonatal Fc receptor". Eur. J. Immunogenet. ج. 27 ع. 4: 231–40. DOI:10.1046/j.1365-2370.2000.00225.x. PMID:10998088.
Zhu X، Meng G، Dickinson BL، Li X، Mizoguchi E، Miao L، Wang Y، Robert C، Wu B، Smith PD، Lencer WI، Blumberg RS (2001). "MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells". J. Immunol. ج. 166 ع. 5: 3266–76. DOI:10.4049/jimmunol.166.5.3266. PMC:2827247. PMID:11207281.
Ober RJ، Radu CG، Ghetie V، Ward ES (2001). "Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies". Int. Immunol. ج. 13 ع. 12: 1551–9. DOI:10.1093/intimm/13.12.1551. PMID:11717196.
Praetor A، Hunziker W (2002). "beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn". J. Cell Sci. ج. 115 ع. Pt 11: 2389–97. PMID:12006623.
Claypool SM، Dickinson BL، Yoshida M، Lencer WI، Blumberg RS (2002). "Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin". J. Biol. Chem. ج. 277 ع. 31: 28038–50. DOI:10.1074/jbc.M202367200. PMC:2825174. PMID:12023961.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Praetor A، Jones RM، Wong WL، Hunziker W (2002). "Membrane-anchored human FcRn can oligomerize in the absence of IgG". J. Mol. Biol. ج. 321 ع. 2: 277–84. DOI:10.1016/S0022-2836(02)00626-5. PMID:12144784.
Shah U، Dickinson BL، Blumberg RS، Simister NE، Lencer WI، Walker WA (2003). "Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine". Pediatr. Res. ج. 53 ع. 2: 295–301. DOI:10.1203/01.pdr.0000047663.81816.e3. PMC:2819091. PMID:12538789.
Chaudhury C، Mehnaz S، Robinson JM، Hayton WL، Pearl DK، Roopenian DC، Anderson CL (2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. ج. 197 ع. 3: 315–22. DOI:10.1084/jem.20021829. PMC:2193842. PMID:12566415.
Schilling R، Ijaz S، Davidoff M، Lee JY، Locarnini S، Williams R، Naoumov NV (2003). "Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions". J. Virol. ج. 77 ع. 16: 8882–92. DOI:10.1128/JVI.77.16.8882-8892.2003. PMC:167249. PMID:12885906.
Zhou J، Johnson JE، Ghetie V، Ober RJ، Ward ES (2003). "Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G". J. Mol. Biol. ج. 332 ع. 4: 901–13. DOI:10.1016/S0022-2836(03)00952-5. PMID:12972260.
Cianga P، Cianga C، Cozma L، Ward ES، Carasevici E (2003). "The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland". Hum. Immunol. ج. 64 ع. 12: 1152–9. DOI:10.1016/j.humimm.2003.08.025. PMID:14630397.
Ober RJ، Martinez C، Vaccaro C، Zhou J، Ward ES (2004). "Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn". J. Immunol. ج. 172 ع. 4: 2021–9. DOI:10.4049/jimmunol.172.4.2021. PMID:14764666.

هذه بذرة مقالة عن بروتين بحاجة للتوسيع. فضلًا شارك في تحريرها.

[1] "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha". مؤرشف من الأصل في 2010-12-05.

[pmid7964511-2] Story CM، Mikulska JE، Simister NE (ديسمبر 1994). "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus". J. Exp. Med. ج. 180 ع. 6: 2377–81. DOI:10.1084/jem.180.6.2377. PMC:2191771. PMID:7964511.

[pmid8646894-3] Kandil E، Egashira M، Miyoshi O، Niikawa N، Ishibashi T، Kasahara M، Miyosi O (يوليو 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet. Cell Genet. ج. 73 ع. 1–2: 97–8. DOI:10.1159/000134316. PMID:8646894.

[1]

[2]

[3]